The cytotoxicity of the formulations was evaluated using the MTT reduction test and was found to be lower compared to the free drug. The optimized formulation showed no substantial changes in these parameters during storage for up to 30 days at ambient temperature. The physicochemical properties of the suspensions (particle diameter, polydispersion, and encapsulation efficiency) were measured as a function of time in order to determine the stability of the formulations. In this work, liposomal formulations were optimized using experimental design methodology, considering the following parameters: average particle diameter, polydispersion, zeta potential, and ATC encapsulation efficiency. The development of new liposomal formulations involves the stages of preparation, physicochemical characterization, and evaluation of stability. Articaine (ATC) is a local anesthetic (LA) used in dental procedures, regional anesthesia, and the control of acute and chronic pain. Advantages of these systems include protection of the active principle against degradation, modulation of the rate of drug release, and lower toxicity. There has been increasing interest in the use of liposomes as carrier systems for pharmaceuticals.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |